ISAM Webinar: Aerosols in the Lung: Lessons Learned from Linking Imaging Data with In Silico Models

Title: Aerosols in the Lung:Lessons Learned from Linking Imaging Data with Computational Models

Tuesday, 24th May 2022

• 8 am – 9 am (San Diego, CA); 11 am – 12 am (New York, NY); 5 pm – 6 pm (Paris, France)
• Follow this link to register for the zoom webinar: https://us06web.zoom.us/webinar/register/WN_atXlALJSQZ2g2Jx5ALEhJQ

• Carsten Ehrhardt
• Barbara Rothen-Rutishauser (ISAM president)
  

Webinar content

Respiratory diseases cause a substantial medical and financial burden worldwide and are often caused by inhalation of air pollution or cigarette smoke over a long period of time. Aerosolized medicine is an effective way to treat these diseases, however targeted lung delivery remains a challenge, especially in the presence of disease. Physiologically based computer simulations provide novel insight into lung dynamics; however, these models must incorporate patient-specific data to be predictive. In this webinar, I will first introduce our new simulation framework that features the ability to couple hyperpolarized 3He MRI with patient-specific models to predict gas flows and respiratory mechanics in healthy and asthmatic lungs. Next, I will present our work on particle dosimetry and therapeutic targeting to specific lung regions. At the end of the talk, I will discuss the challenge of validating computer models and my perspective on what is required to bring these types of models into clinical practices.

About the presenter

Dr Jessica Oakes is an Assistant Professor at Northeastern University in Boston, Massachusetts. Jessica directs the Respiratory Innovation and Simulation Team (RESIST) and co-directs the Integrated Cardiovascular and Pulmonary (ICAP) team. Her research group focusses on combining experimental and numerical techniques to predict, quantify, and optimise aerosol dosimetry and the corresponding structure/function response in the lung.