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Anatomical oropharyngeal model

International Society for Aerosols in Medicine

A premiere forum for medical and environmental aerosols

Courtesy: Tim Corcoran
Courtesy: Tim Corcoran
Courtesy: Tim Corcoran
21st ISAM Congress - Santa Fe 2017
Fiesta Dancers
21st ISAM Congress - Santa Fe 2017
21st ISAM Congress - Santa Fe 2017
21st ISAM Congress - Santa Fe 2017
21st ISAM Congress - Santa Fe 2017
21st ISAM Congress - Santa Fe 2017
21st ISAM Congress - Santa Fe 2017

The Oropharyngeal consortium, comprising scientists from AstraZeneca, GlaxoSmithKline and sanofi-aventis, funded the collection of a dataset of three-dimensional oropharyngeal (OP) images from healthy adults by MRI. The aims were to obtain dimensional information that is representative of the adult population (1), to investigate factors that may affect the OP airspaces (2, 3), to determine the key parameters governing OP deposition (4), and to identify physical models that may represent high, medium and low OP deposition for the purpose of in vitro characterization of inhalation products (5). The three identified models (made available here as stl-files) were subsequently used in an in vitro – in vivo correlation study (6).

  1. McRobbie, D.W., Pritchard, S. and Quest, R.A. (2003), “Studies of the human oropharyngeal airspaces using magnetic resonance imaging III - The effect of breathing and body posture on the oropharyngeal airspace geometry”, J. Aerosol Med., 18(3), 325-336.
  2. Pritchard, S.E. and McRobbie, D.W. (2004), “Studies of the human oropharyngeal airspaces using magnetic resonance imaging I – Validation of a three-dimensional MRI methodfor producing ex-vivo virtual and physical casts of the oropharyngeal airways during inspiration”, J. Aerosol Med., 16(4), 401-415.
  3. McRobbie, D.W., Quest, R.A., and Pritchard, S. (2005), “Studies of the human oropharyngeal airspaces using magnetic resonance imaging III - The effect of breathing and body posture on the oropharyngeal airspace geometry”, J. Aerosol Med., 18(3), 325-336.
  4. Grgic, B., Heenan, A.F., and Finlay, W.H. (2004), “In vitro intersubject and intrasubject deposition measurement in realistic mouth-throat geometries”, J. Aerosol Sci., 35, 1025-1040.
  5. Burnell, P.K.P., Asking, L., Borgström, L., Nichols, S., Olsson, B., Prime, D., and Shrubb, I. (2007), “Studies of the human oropharyngeal airspaces using magnetic resonance imaging IV - The oropharyngeal retention effect for four inhalation delivery systems”, J. Aerosol Med., 20(3), 269-281.
  6. Olsson, B., Borgström, L., Svensson, M. and Lundbäck, H. (2008), “Modeling Oropharyngeal Cast Deposition to Predict Lung Delivery from Powder Inhalers”, in Respiratory Drug Delivery 2008, Davis Healthcare International Publishing, LLC, River Grove, Illinois (USA), Vol 1, pp 197-205.

You can download the 3D model

Model L - small

Model C - medium

Model D - large

 

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